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Coverage of genome expression and replication is truly genomic, concentrating. Home [P. Phillip Keller [P. Walker [P. Carlucci [P. Okeson [P. Zar [P. Price [P. Pedroni [P. Britz [P. Todaro [P. Hibbeler [P.

Rajput [P. Rowling [P. Donatelle [P. Baker MD [P. Back in , next-generation sequencing was in its infancy and high-throughput meth-ods for transcriptomics and proteomics were only beginning to be exploited. The application of these methods over the last ten years has resulted in an exponential increase in the number of species for which genome sequences and annotations are now available and single species to be examined by multiple versions of the genome.

The profusion of new sequences has had a particularly dramatic impact on bacterial genomics, with the introduction of the pan-genome concept and the discovery of extensive lateral transfer of genes between species.

Our knowledge of eukaryotic genomes has an under-gone equally dramatic change, with the discovery of new types of noncoding RNA, including the vast numbers of long RNAs that are transcribed from the supposedly intergenic regions of many genomes. Genomes 4th edition retains the overall structure of the previous editions, with the book divided into four parts, on genome sequencing and annotation , genome anatomies , genome expression , and genome replication and evolution.

With some small changes, the order of chapters remains unchanged.